Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs.
The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer.
Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology.
- Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy.
- Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology.
- Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.
About the Author
Dr. Chandrashekhar Gandhi is a professor within the department of Surgery at the University of Cincinnati. His laboratory focuses on the mechanisms of intercellular communications that regulate the structure and function of the liver in physiology and pathology. Present research elucidates specific molecular and biochemical mechanisms underlying effects of stellate cells.