Antisepsis, Disinfection, and Sterilization: Types, Action, and Resistance, by Gerald E. McDonnell, is a detailed and accessible presentation of the current methods of microbial control. Each major category, such as physical disinfection methods, is given a chapter, in which theory, spectrum of activity, advantages, disadvantages, and modes of action of the methods are thoroughly and clearly presented. Sufficient background on the life cycles and general anatomy of microorganisms is provided so that the reader who is new to microbiology will better appreciate how physical and chemical biocides work their magic on microbes. Other topics in the book include:
- Evaluating the efficacy of chemical antiseptics and disinfectants, and of physical methods of microbial control and sterilization.
- Understanding how to choose the proper biocidal product and process for specific applications.
- Classic physical and chemical disinfection methods, such as heat, cold, non-ionizing radiation, acids, oxidizing agents, and metals.
- Newer chemical disinfectants, including, isothiazolones, micro-and nano-particles, and bacteriophages as control agents.
- Antisepsis of skin and wounds and the biocides that can be used as antiseptics.
- Classic methods of physical sterilization, such as, moist heat and dry heat sterilization, ionizing radiation, and filtration, along with newer methods, including, the use of plasma or pulsed light.
- Chemical sterilization methods that use ethylene oxide, formaldehyde, or a variety of other oxidizing agents.
- A detailed look at the modes of action of biocides in controlling microbial growth and disrupting microbial physiology.
- Mechanisms that microorganisms use to resist the effects of biocides.
The second edition of Antisepsis, Disinfection, and Sterilization: Types, Action, and Resistance is well suited as a textbook and is outstanding as a reference book for facilities managers and application engineers in manufacturing plants, hospitals, and food production facilities. It is also essential for public health officials, healthcare professionals, and infection control practitioners.
About the Author
Gerald E. McDonnell received a B.Sc. degree in medical laboratory sciences from the University of Ulster (1989) and a Ph.D. in microbial genetics at the Department of Genetics, Trinity College, University of Dublin (1992). His graduate work involved studies on the control of gene expression in Bacillus subtilis. He spent 3 years at the Mycobacterial Research Laboratories, Colorado State University, investigating the mechanisms of antibiotic resistance and cell wall biosynthesis in mycobacteria.
In 1995 he joined the St. Louis, Mo., operations of ConvaTec, a division of Bristol-Myers Squibb, as a group leader in microbiology in the research and development of skin care, hard surface disinfection, and cleaning chemistries. He worked for STERIS Corporation for 19 years in the USA and in Europe on the development, research, and support of infection and contamination prevention products and services in health care and industrial applications, with a particular focus on cleaning, antisepsis, disinfection, and sterilization.
Dr. McDonnell is currently the senior director for sterility assurance for DePuySynthes, a Johnson & Johnson company, and a member of the Johnson & Johnson Sterility Assurance leadership team. He serves as the global technical leader in the areas of microbiology and contamination control including sterilization, aseptic technique, reprocessing, microbiology, and cleanliness requirements. His basic research interests include infection prevention, decontamination microbiology, emerging pathogens, and modes of action and resistance to biocides.
His work also includes the development and implementation of international and national guidance and standards in cleaning, disinfection, and sterilization. He has over 180 publications, 22 patents and is a frequent presenter on various aspects of his work internationally.
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